Camptothecin prodrug
WebNov 14, 2003 · Abstract. 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (irinotecan, CPT-11) is a camptothecin prodrug that is metabolized by carboxylesterases (CE) to the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38), a topoisomerase I inhibitor. CPT-11 has shown encouraging antitumor activity against a broad spectrum of … WebA camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations - Chemical Communications (RSC Publishing) Issue 84, 2024 Previous Article Next Article From the journal: Chemical Communications A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations †
Camptothecin prodrug
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WebSep 20, 2024 · Minimizing drug leakage in systemic circulation, synchronizing the in vivo fate of multiple drugs, and precisely controlling tumor locoregional drug release, remain … WebJul 12, 2024 · Prodrug–prodrug activation Camptothecin 4 is a topoisomerase I inhibitor that induces S-phase specific cell death. Since its discovery in the 1960's, several camptothecin derivatives and prodrugs have been reported with the aim of overcoming the drawbacks associated with camptothecin such as solubility and the stability of the …
WebNational Center for Biotechnology Information WebAbstract A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate linker. The conjugate was found to possess high affinity for folate receptor-expressing cells and inhibited cell proliferation in human KB cells with an IC 50 of 10 nM.
National Center for Biotechnology Information WebNov 28, 2013 · However, administration of a high dose of SN38 or its prodrug CPT-11 is limited by the severe side effects. The most common dose-limiting toxicity (DLT) for CPT-11 or SN38 therapy is delayed diarrhoea and myelosuppression; ~ 35% of the treated patients were reported with Grade 3 or 4 diarrhoea and 14–47 were reported with Grade 3 or 4 …
WebSep 20, 2024 · Here, a reactive oxygen species (ROS)-responsive camptothecin (CPT) prodrug delivery system (MPEG- (TK-CPT)-PPa) is developed, in which CPT and photosensitizer pyropheophorbide-a (PPa) are concurrently conjugated to the same poly (ethylene glycol) methyl ether (MPEG) via ROS-responsive thioketal (TK) and lipid linkage.
WebSep 20, 2024 · The construction of prodrug and glucose oxidase coloaded alginate (ALG) hydrogels for PDT-combined chemotherapy of melanoma will provide a promising injectable hydrogel platform for effective treatments of cancer. Biomimetic nanoprodrugs from fatty acid modified camptothecin and albumin for enhanced pharmacotherapy. port care waiting timeWebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon … port cares nickel streetWebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ... irish products not available in americaWebEster prodrugs are most often used to enhance the lipophilicity, and thus the passive membrane permeability, of water-soluble drugs by masking charged groups such as carboxylic acids and... port cares 50/50 winnerWebSep 11, 2007 · Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme … port cares housing listWebFeb 4, 2024 · Conventional chemotherapy and targeted therapy promote the antitumor immune response by increasing the immunogenicity of tumor cells, improving CD8+ T cell infiltration, or inhibiting immunosuppressive cells in the tumor microenvironment. irish pronunciations eeWebDec 1, 2024 · Self-assembled prodrugs (SAPDs), which combine prodrug strategy and the merits of self-assembly, not only represent an appealing type of therapeutics, enabling the spontaneous organization of supramolecular nanocomposites with defined structures in aqueous environments, but also provide a new method to formulate existing drugs for … irish proclamation 1916 text