Phospholipidosis liver
WebOct 1, 2014 · @article{osti_22439848, title = {Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug}, author = {Mosedale, Merrie and Wu, Hong and Kurtz, C. Lisa and Schmidt, Stephen P. and Adkins, Karissa and Harrill, Alison H. and University of Arkansas for … WebJun 29, 2012 · The liver plays a key role in fat metabolism, and excessive lipid accumulation in liver cells is characterised by a large spectrum of lesions, e.g., steatosis and phospholipidosis.
Phospholipidosis liver
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Webation. For the hepatic phospholipidosis samples, archival paraffin-embedded tissue blocks were utilized from a 7-day dose-range finding study of an experimental compound that had cationic amphiphilic properties and caused dis-seminated phospholipidosis in dosed-rats as observed by light microscopic examination and confirmed via electron ... WebPhospholipidosis can develop in Kupffer cells within the liver and other organs as well. In most cases, phospholipidosis is reversible upon discontinuation of the drug or chemical. Sign in to download full-size image FIGURE 45.26. Electron micrograph of phospholipidosis within bile duct epithelium.
WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually … WebApr 23, 2024 · Lee et al. created 3D hepatic organoids to predict drug-induced phospholipidosis (PL). They isolated duct cells from human liver tissue and embedded them in Matrigel, followed by the addition of ...
WebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. [1] [2] [3] Certain cases may be triggered by medications. [4] … WebApr 23, 2024 · Drug-induced phospholipidosis (PL) is a storage disorder caused by the formation of phospholipid-drug complexes in lysosomes. Because of the diversity of PL between species, human cell-based assays have been …
WebApr 27, 2009 · About 18 months after taking amiodarone, liver enzymes were noted to have increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium, compared to that of the spleen and surrounding tissues (113 Hounsfield units (H), normal range of the liver is about …
WebScreen for drug-induced liver phospholipidosis and steatosis Cationic amphiphilic drugs are often associated with the induction of phospholipidosis, which is believed to be a precursor event to liver toxicity. readington starfishWebPhospholipidosis appears to be a generalized systemic effect of cationic amphophilic compounds, such as AD. The cytotoxic pseudoalcoholic changes appear to be an independent phenomenon in susceptible patients, whom we speculate may have been unable or less able to metabolize AD through normal pathways. readington school district employmentWebJan 20, 2024 · For example, excess storage of these molecules in nerve tissues can cause developmental disabilities, accumulation in the tissues of the spleen and liver can cause poor functioning of these vital organs, and excess storage in the bone marrow can damage bones, leading to skeletal deformities. how to sword fight for beginnersWebApr 6, 2024 · They serve as a repository of various lipids and are associated with many cellular metabolic processes, including energy storage, membrane synthesis, and protein homeostasis. LDs are prominent in a variety of diseases related to lipid regulation, including obesity, fatty liver disease, diabetes, and atherosclerosis. readington sewerWebSep 1, 2013 · Ketoconazole was reported to cause phospholipidosis in the liver, lung and spleen (Whitehouse et al., 1994, Pakuts et al., 1990), but little is known about its effects on the kidneys in humans or animals. Thus, our findings about renal phospholipidosis are the first of their kind in ketoconazole-treated mice. how to switch zoom cameraWebPhospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of intracellular phospholipids in tissues, such as the liver, kidney and lung. It is well … how to sword lunge sea of thievesWebPhospholipidosis is an excessive intracellular accumulation of phospholipids and drug, which is normally reversible after discontinuation of drug treatment. Currently, it is … readington township building dept