Web1 Oct 2013 · TGF-B1 is generally produced as a large latent complex (LLC) in which LAP-TGF-B1 (small latent complex [SLC]) is bound to another high-molecular-weight protein called LTBP [14, 15], which gives rise to a pro-TGF-B1-LAP and LTBP complex of ∼220 to ∼235 kDa in size . WebTGF-beta/Smad Signaling Pathway Map. Biological Activity. Description: SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, ... Molecular Weight: 384.39: Formula: C 22 H 16 N 4 O 3. CAS No. 301836-41-9: Storage: 3 years-20°C: powder: 1 years-80°C: in solvent: Shipping:

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Web5 Apr 2011 · Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide ... WebLatency-associated peptide. Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix ( By similarity ). Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control ... jean\\u0027s 2022 spreadsheet

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Web11 Apr 2024 · Molecular weight (Mw) is another important structural parameter of chitosan. Chitin, ... TGF-β1 was covalently conjugated to MeGC via an SMCC linker prior to COL II interpenetration. IC or CC hydrogels were then formed by VBL irradiation with RF as an initiator (Choi et al., 2015). (For interpretation of the references to colour in this figure ... WebApparent Molecular Weight ~12 kDa, on SDS-PAGE under reducing conditions. Formulation: Lyophilized from a 0.2 μm filtered solution in 50 mM NaAc, 50 mM NaCl, pH 5.0. ... TGF-beta-1; CED; DPD1; TGFB; TGF-b1; TGFB1; CEDLAP; latency-associated peptide; TGF beta; TGF-beta 1 protein; transforming growth factor beta-1 ... Web8 Nov 2024 · Transforming growth factor-beta, or TGFB (see TGFB1; 190180 ), remains biologically latent after secretion, blocked from activity by its N-terminal propeptide (the latency-associated peptide, or LAP). TGFB is activated by its dissociation from LAP. The latent form of TGFB is secreted in association with a latent TGFB-binding protein, or LTBP ... jean\u0027s 24